Santee, SC is located in the Lowcountry region of South Carolina. The area is known for its natural beauty, including the nearby Santee Cooper Lakes, which are popular for fishing and boating. The town is also home to several golf courses, making it a popular destination for golf enthusiasts. Some of the local entertainment business attractions include Santee National Golf Course, Santee State Park and Santee Cooper Country Club. Santee is located about 35 miles from Orangeburg, SC (population of about 13,964) and about 40 miles from Columbia, SC (population of about 133,114)